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Tutorials


Ram Samudrala

Gianfranco Gilardi

Raffaele Calogero

Francesca Cordero

Session 1
October 15, 2014, 14:30 – 16:15
Modelling Interactomes: From Genotype to Phenotype
Ram Samudrala,
University of Washington, Seattle, USA

Ram Samudrala is professor of computational biology and bioinformatics at the University of Washington. He researches protein and proteome structure, function, interaction, design, and evolution spanning atomic to organismal levels of description. He published more than 110 works and he is author of free software and web servers for molecular and systems modelling.
The tutorial will present an overview with examples on how different modelling approaches are accomplished in the following focus areas, with emphasis on protein structure prediction methods:
Structure, Function, Systems, Evolution, Design, Application, Infrastructure.
For further details see Ram Samudrala Tutorial page.
October 15, 2014, 16:45 – 18:30
Protein Engineering and Drug Design Based on 3D Protein Models
Gianfranco Gilardi,
University of Torino, Italy

Gianfranco Gilardi, Biologist, got a Ph.D. in Biotechnology and the Diploma of Imperial College, at the Imperial College London in 1991. He is Full Professor of Biochemistry at the University of Torino since 2001. His present teaching duties include both the Biochemistry and the Protein Engineering and Drug Design courses. He is Editor-in-Chief of the American journal Biotechnology and Applied Biochemistry, Wiley, and Editor of the Inorganic Chemistry board of The Scientific World Journal, beside being fellow of various scientific societies.
He is author of ca. 80 refereed papers, 11 chapters in edited books, and 11 patents. Invited speaker ca. 40 international congresses, workshops and seminar series, as well as organiser and chairman to 8 international meetings. Referee to many funding bodies and international journals, as well as scientific consultant to Pfizer Sandwich (Kent), Scientific founder of Imperial College spin off NanoBioDesign Ltd (London), for which he also acted as Chief Scientific Officer till 2010.
His research is focused on redox systems with particular reference to electron transfer proteins and monooxygenase enzymes. Current projects range from engineering human aromatase for structural-functional studies of sex hormones metabolism to engineering versatile artificial four helix bundles for bioelectronic devices, functional studies of hydrogenase for the construction of an artificial leaf for alternative energy sources.
This tutorial will describe in practice the process carried out in pharmaceutical companies in the initial steps of drug design. During the tutorial, a 3D model of a protein target will be constructued by homology modelling. The quality of the model will then be assessed online by bioinformatics tools. Molecular docking with a drug will then be performed and the docking poses analysed. The prediction of the interaction between a protein and a substrate/inhibitor will also be explored.
For further details see Gianfranco Gilardi Tutorial page.

Session 2
October 15, 2014, 14:30 – 16:15
Next generation data analysis using OneChannelGUI
Raffaele Calogero,
University of Torino, Italy

Raffaele Calogero CV and research interests will be added here.
Talk abstract to be added here.
For further details see Raffaele Calogero Tutorial page.
October 15, 2014, 16:45 – 18:30
How to use next generation data to build and analyse a model
Francesca Cordero,
University of Torino, Torino, Italy

Francesca Cordero CV and research interests will be added here.
Talk abstract to be added here.
For further details see Francesca Cordero Tutorial page.

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